TOXICOLOGICAL SIGNIFICANCE OF DRUG USE IN LIFE STAGES

Course Description

This course covers introduction to safety drug use in life stages and fundamental concepts, safety drug use in pregnancy, placental transfer of drugs in pregnancy, how drugs affect the fetus, commonly used drugs in pregnancy and their categories, FDA categorization of drugs for use in pregnancy, list of teratogens, (pharmacokinetic and pharmacodynamic) factors that are altered in childhood and elderly, safety use of drugs and factors that may affect therapy in these age groups, the safety use of herbal medicinal products and their interactions with drugs in these age groups, drug-nutrient interactions in these age groups, medication errors in elderly and patient safety, polypharmacy in elderly and its consequences clinically important drug–disease Interactions, polypharmacy in children and its consequences.

TOXICOLOGICAL SIGNIFICANCE OF DRUG USE IN LIFE STAGES

Evaluation Tools (Active Term)

Course outcomes

1. 01 1.Be able to explain the significance of the pharmaco/toxicokinetics and pharma/toxicodynamics of the drugs in pregnancy for the safety use of drugs.
2. 02 2.Be able to explain and compare the safety use of herbal medicinal products in pregnancy, breastfeeding and elderly and also drug-herbal product interactions and assess possible clinical and toxicological consequences.
3. 03 3.Be able to explain pharmaco/toxicokinetics and pharmaco/toxicodynamics of drugs in neonates and childhood and the factors affecting pediatric therapy.
4. 04 4.Be able to explain pharmaco/toxicokinetics and pharmaco/toxicodynamics of drugs in elderly and the factors affecting geriatric therapy.
5. 05 5.Be able to identify and compare the drug-nutrient interactions in infants, adults and elderly and assess possible clinical and toxicological consequences.
6. 06 6.Be able to describe polypharmacy in elderly and assess possible clinical and toxicological consequences.

Course Syllabus

Reference Books & Course Materials

1. 01 Klaasen CD, Watkins JB. Casarette & Doull’s Essentials of Toxicology. McGraw-Hill Comp., North America, 2010.
2. 02 Coleman MD. Human Drug Metabolism, Wiley-Blackwell, Oxford, 2010
3. 03 Boulatta JI, Armenti. Handbook of drug nutrient interactions, Humana Press, USA. 2020
4. 04 AHPA's Botanical Safety handbook, 2nd ed., North America, 2013

Learning Outcomes

1. L01 Explain (3) the significance of the pharmaco/toxicokinetics and pharma/toxicodynamics of the drugs in pregnancy for the safety use of drugs SOLO 3
2. L02 Explain (3) and compare (5) the safety use of herbal medicinal products in pregnancy, breastfeeding and elderly and also drug-herbal product interactions and assess (5) possible clinical and toxicological consequences SOLO 4.33
3. L03 Explain (3) pharmaco/toxicokinetics and pharmaco/toxicodynamics of drugs in neonates and childhood and the factors affecting pediatric therapy SOLO 3
4. L04 Explain (3) pharmaco/toxicokinetics and pharmaco/toxicodynamics of drugs in elderly and the factors affecting geriatric therapy SOLO 3
5. L05 Identify (2) and compare (5) the drug-nutrient interactions in infants, adults and elderly and assess (5) possible clinical and toxicological consequences SOLO 4
6. L06 Describe(3) polypharmacy in elderly and assess (5) possible clinical and toxicological consequences SOLO 4

Program Outcomes

1. P01 Gain the ability to apply the Pharmacy profession.
2. P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
3. P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
4. P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
5. P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
6. P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
7. P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
8. P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
9. P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
10. P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
11. P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
12. P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
13. P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
14. P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix