BIOPHARMACEUTICS PHARMACOKINETICS
- Course
- PHAR402 - BIOPHARMACEUTICS PHARMACOKINETICS
- Department
- Pharmacy - English - Undergraduate
- Course Type
- Course
- Status
- Required
- Language
- English
- Credit
- 2
- ECTS
- 6
- T+P+L
- 2 + 0 + 0
- Course Coordinator(s)
- Assoc. Prof. Dr. Muhammad SOHAIL
- Prerequisite
- -
- Keywords
Course Description
Biopharmaceutics is the science that examines the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption. Pharmacokinetics (PK) is the study and characterization of the kinetics of drug Absorption, Distribution, Metabolism and Elimination (ADME). In this course the students will learn linear PK, non-linear PK, mechanism and interrelationship of ADME, transportation mechanisms of drugs, bioclassification of drugs, effective factors on bioavalibility of drugs, increasing methods of BA, bioequivalence(BE) studies, calculation of volume of distribution, clearance, pharmacokinetic parameters, absolute bioavailibility, relative bioavalibility (BA), similarity and dissimilarity factors.
BIOPHARMACEUTICS PHARMACOKINETICS
Evaluation Tools (Active Term)
No evaluation items have been defined.
Course outcomes
- 01 1.Be able to explain Routes of administration of drugs, dosage forms.
- 02 2.Be able to explain ADME (LADME), distrubition of metabolism, excretion of drugs.
- 03 3.Be able to explain Volume of distrubition and clearence
- 04 4.Be able to describe Metabolism of drugs and
- 05 5.Be able to explain Classification of drugs from the points of functional groups.
- 06 6.Be able to explain Bioclassification of Drugs and Factors effective on bioavailability
- 07 7.Be able to explain Factors effective on bio availability and Absolute and relative bioavailability, calculation of AUC, calculation of bioavailability
- 08 8.Be able to explain Bioequivalence and biowaver conditions, Release profiles, F2 and F1 factors
- 09 9.Be able to explain Drug delivery systems and release kinetics. andDosage forms with zero order release and matrix kinetics, microencapsulation.
- 10 10.Be able to explain Dosage forms with zero order release and matrix kinetics, microencapsulation andTransdermal dosage forms and patches.
Course Syllabus
| Week | Topic |
|---|---|
| Week 1 | Basic definitions, Biopharmaceutics and Pharmacokinetics |
| Week 2 | Measurement of Drug Concentrations and Sampling of Biologic Specimens |
| Week 3 | Plasma Level–Time Curve |
| Week 4 | Bioavailability and Bioequivalence and Basic Terminologies |
| Week 5 | Objectives of Bioavailability Studies |
| Week 6 | Relative and Absolute Bioavailability |
| Week 7 | AI/ML-Based Prediction of Drug Absorption, Bioavailability and Pharmacokinetic Parameters |
| Week 8 | Methods of in-vitro and in-vivo Assessing Bioavailability |
| Week 9 | Methods of in-vitro and in-vivo Assessing Bioavailability |
| Week 10 | Drug Products with Possible Bioavailability and Bioequivalence Problems |
| Week 11 | Design and Evaluation of Bioequivalence Studies |
| Week 12 | Pharmacokinetic parameters, Application of pharmacokinetics in clinical situations. |
| Week 13 | Protein binding, metabolization, excretion, pharmacokinetic parameters |
| Week 14 | Protein binding, metabolization, excretion, pharmacokinetic parameters |
| Week 15 | Final Exams |
Reference Books & Course Materials
- 01 Applied Biopharmaceutics & Pharmacokinetics" by Leon Shargel
Learning Outcomes
No learning outcomes have been defined.
Program Outcomes
- P01 Gain the ability to apply the Pharmacy profession.
- P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
- P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
- P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
- P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
- P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
- P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
- P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
- P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
- P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
- P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
- P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
- P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
- P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.
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