PHARMACEUTICAL BIOTECHNOLOGY

Course Description

Applications of recombinant DNA technology in the pharmaceutical sciences, PCR and mutagenesis in gene engineering, biotechnology derived protein products, vaccines, monoclonal antibodies and pharmaceutical applications, gene therapy, and viral and non-viral delivery of gene therapeutics, usage of transgenic animals for production of biopharmaceuticals, analytical methods used in pharmaceutical biotechnology, mechanisms and causes of protein purification/destabilization, methods used to evaluate protein pharmaceuticals, developments in protein drug delivery, regulatory aspects of biotechnology-based pharmaceuticals, principles of cell culture, preparation, and maintenance of cell lines will be covered. Vaccines, immunoglobulin products, monoclonal antibodies, products containing cells or microorganisms, interferons, therapeutic proteins derived from plants, animals, humans, or microorganisms, and recombinant versions of these products, and quality control of biological products and regulatory issues are also included with particular attention to methods.

PHARMACEUTICAL BIOTECHNOLOGY

Evaluation Tools (Active Term)

Course outcomes

1. 01 1. Be able to fully evaluate molecular basis of major biotechnology techniques
2. 02 2. Be able to comprehend, apply and describe the basic principles of pharmaceutical biotechnology.
3. 03 3. Be able to explain important features of new advances in pharmaceutical biotechnology
4. 04 4. Be able to search and interpret, critically evaluate and present multidisciplinary scientific articles.
5. 05 5. Be able to present on biotechnology methods and techniques using scientific literature.
6. 06 6-Pharmaceuticals (including antibiotics, small molecular drugs) produced using Pharmaceutical Biotechnology techniques
7. 07 7-Production methodologies in pharmaceutical biotechnology ( recombinant DNA technology, fermentation methods, hybridoma and transgenic technologies)
8. 08 8-Obtain knowledge about stem cell technology and therapies, biosimilars, tissue engineering and their associated risk factors and management, ethical and administrative responsibilities of the pharmacist.
9. 09 9-Pharmaceutical bionanotechnology, gene based drugs, genetic tests, biobanks, personalized medicine, omics technologies and basics of bioinformatics.

Course Syllabus

Reference Books & Course Materials

1. 01 Pharmaceutical Biotechnology - Fundamentals and Applications by Crommelin et al., Informa Healthcare USA, ISBN: 1-4200-4437-0
2. 02 Pharmaceutical Biotechnology- Concepts and Applications by Gary Walsh, Wiley & Sons, ISBN 978-0-470-01245-1 (PB)

Learning Outcomes

1. L01 1. Be able to fully evaluate molecular basis of major biotechnology techniques SOLO 4
2. L02 2. Be able to apply and describe the basic principles of pharmaceutical biotechnology. SOLO 4
3. L03 3. Be able to explain and evaluate important features of new advances in pharmaceutical biotechnology SOLO 4
4. L04 4. Be able to search and interpret, critically evaluate and present multidisciplinary scientific articles. SOLO 4
5. L05 5. Be able to present on biotechnology methods and techniques using scientific literature. SOLO 4
6. L06 6-Pharmaceuticals (including antibiotics, small molecular drugs) produced using Pharmaceutical Biotechnology techniques can be explained SOLO 4
7. L07 7-Assesses production methodologies in pharmaceutical biotechnology ( recombinant DNA technology, fermentation methods, hybridoma and transgenic technologies) SOLO 4
8. L08 8-Describe stem cell technology and therapies, biosimilars, tissue engineering and their associated risk factors and management, ethical and administrative responsibilities of the pharmacist. SOLO 4
9. L09 9- Identify, evaluate and explain Pharmaceutical bionanotechnology, gene based drugs, genetic tests, biobanks, personalized medicine, omics technologies and basics of bioinformatics. SOLO 4

Program Outcomes

1. P01 Gain the ability to apply the Pharmacy profession.
2. P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
3. P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
4. P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
5. P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
6. P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
7. P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
8. P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
9. P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
10. P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
11. P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
12. P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
13. P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
14. P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix