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Cyprus International University
TR

PHARMACEUTICAL CHEMISTRY-II

Course
PHAR303 - PHARMACEUTICAL CHEMISTRY-II
Department
Pharmacy - English - Undergraduate
Course Type
Course
Status
Required
Language
English
Credit
3
ECTS
5
T+P+L
2 + 0 + 3
Course Coordinator(s)
Asst. Prof. Dr. Mohammed T. N. QAOUD
Prerequisite
-
Keywords

Course Description

Autonomic nervous system drugs, cardiovascular system drugs such as cardiac glycosides, antiarrhythmics, antianginals, central nervous system drugs such as sedatives and hypnotics, general and local anesthetics, anticonvulsants, opiates, antihistamines, NSAIDs, anti-ulcer drugs, drugs affecting the hormonal system, functional group analysis, qualitative analysis of drugs with conventional and spectral methods such as UV, IR, H-NMR, mass spectroscopy, and structure determination are the main topics. Paper, thin layer, column and high pressure liquid chromatography techniques and their applications in drug analysis, separation of solid-solid and liquid-liquid mixtures, determination of some physical parameters such as density, boiling point and melting point, measurement of refraction index and determination of specific rotation, drug metabolism and pharmacopoeia analysis will also be performed.

PHARMACEUTICAL CHEMISTRY-II

Evaluation Tools (Active Term)

Item Type Weight (%)
Phar303-Midterm Midterm 30
Phar303-Final Final 45
Phar303-laboratory Quiz 25
Total 100

Course outcomes

  1. 01 Be able to describe structure activity releationship between the receptor/target and the drug
  2. 02 Be able to express and analyze the molecular structures of the drugs
  3. 03 Be able to designs the synthesis reactions of particular drugs
  4. 04 Be able to illustrate IUPAC nomenclature of the medicines
  5. 05 Be able to identify working mechanisms and to structure the metabolism of the medicines

Course Syllabus

Week Topic
Week 1 Explain the fundamental principles of pharmaceutical and medicinal chemistry, including the relationship between chemical structure, physicochemical properties, and pharmacological activity, and apply these principles to selected drug molecules.
Week 2 Explain acidity and basicity in drug molecules, identify ionizable functional groups, and predict how pKa and ionization influence drug properties, absorption, distribution, and activity.
Week 3 Explain the fundamental concepts of structure–activity relationships (SAR) and analyze how structural modifications, functional groups, stereochemistry, and molecular interactions can affect drug potency and selectivity.
Week 4 Classify diuretic drugs according to their chemical structures and mechanisms of action, and relate their key structural features to their pharmacological effects.
Week 5 Explain the role of physicochemical properties in drug action, including lipophilicity, solubility, ionization, hydrogen bonding, molecular size, and electronic properties, and relate these properties to drug–target interactions and pharmacokinetic behavior.
Week 6 Analyze the structure–activity relationships of diuretic drugs and correlate structural modifications with potency, selectivity, pharmacological profiles, and clinical applications.
Week 7 Explain the mechanism of action and chemical basis of ACE inhibition, classify ACE inhibitors according to their structural features, and identify the pharmacophoric elements responsible for ACE-binding activity.
Week 8 Midterm exam
Week 9 Analyze the SAR of ACE inhibitors and explain how structural modifications influence ACE-binding interactions, potency, pharmacokinetic properties, and therapeutic optimization.
Week 10 Classify calcium channel blockers according to their chemical structures and pharmacological classes, and explain their mechanisms of action and major structural characteristics.
Week 11 Analyze the SAR of calcium channel blockers and relate their structural features to receptor/channel interactions, pharmacological profiles, selectivity, potency, and therapeutic applications.
Week 12 Explain the chemical classification, mechanisms of action, and key structural features of antihyperlipidemic drugs, including the major drug classes used to modify lipid metabolism.
Week 13 Analyze the SAR and physicochemical characteristics of selected antihyperlipidemic drugs and correlate structural modifications with target interactions, potency, selectivity, and clinical effects.
Week 14 Integrate pharmaceutical chemistry principles across major cardiovascular drug classes by comparing chemical structures, mechanisms of action, SAR, physicochemical properties, and structure-dependent pharmacological effects of diuretics, ACE inhibitors, calcium channel blockers, and antihyperlipidemic drugs.
Week 15 Final Exam

Reference Books & Course Materials

  1. 01 Introduction to Medicinal Chemistry
  2. 02 Foye's Principles of Medicinal Chemistry

Learning Outcomes

  1. L01 Be able to describe structure activity releationship between the receptor/target and the drug SOLO 3
  2. L02 Be able to express and analyze the molecular structures of the drugs SOLO 3.5
  3. L03 Be able to designs the synthesis reactions of particular drugs SOLO 4
  4. L04 Be able to illustrate IUPAC nomenclature of the medicines SOLO 3
  5. L05 Be able to identify working mechanisms and to structure the metabolism of the medicines SOLO 3

Program Outcomes

  1. P01 Gain the ability to apply the Pharmacy profession.
  2. P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
  3. P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
  4. P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
  5. P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
  6. P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
  7. P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
  8. P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
  9. P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
  10. P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
  11. P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
  12. P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
  13. P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
  14. P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix

LO P01 P02 P03 P04 P05 P06 P07 P08 P09 P10 P11 P12 P13 P14 Average
L01 4 4 4 4 3 3 0 4 0 4 0 4 0 5 2.79
L02 4 4 4 4 3 4 0 0 0 4 0 4 0 5 2.57
L03 4 4 4 4 3 3 0 0 0 4 3 4 0 5 2.71
L04 3 0 4 4 3 3 0 0 0 4 0 0 0 5 1.86
L05 4 4 3 4 4 3 0 0 0 4 0 0 0 5 2.21