PHARMACEUTICAL TOXICOLOGY-II

Course Description

Hepatotoxicity, nefrotoxicity, toxicity of skin, toxicity of pulmonary system, toxicity of cardiovascular system, selective toxicity, toxic effects of pesticides, toxic effects of metals, toxic effects of volatile organic solvents, natural toxins in food, toxic effects of food additives and contaminants, toxic effects of terrestrial animal venoms and poisons and their treatments, toxic effects of plants and their treatments, toxicity of household chemicals, disaster toxicology, toxicological prenciples in juridical cases, air, water, and soil pollution, toxicity of analgesics, toxic effects of the sedative-hypnotics, toxic effects of antihipertansives, toxic effects of the heart and vascular system drugs, toxicity of alcohol, aldehydes, opioids and halusinogenic narcotics, vitamins and their toxic effects, toxicological evaluation of biotechnological products and nanotoxicology will be covered.

PHARMACEUTICAL TOXICOLOGY-II

Evaluation Tools (Active Term)

Course outcomes

1. 01 Be able to describe the mechanism of toxicity and ADME of major toxic substances.
2. 02 Be able to classsify and compare the therapeutic drugs and illustrate how they should be utilized in cases of poisonings.
3. 03 Be able to critically assess the current environmental issues related to industrial and commercial pollution.
4. 04 Be able to evaluate the potential dangers and adverse effects of materials that are used daily.
5. 05 Be able to conduct related laboratory experiments and interpret the obtained scientific results accordingly.
6. 06 -
7. 07 -
8. 08 -
9. 09 -
10. 10 -

Course Syllabus

Reference Books & Course Materials

1. 01 Pharmaceutical Toxicology (ULLA Postgraduate Pharmacy) (2006) By Gerard J. Mulder Ed.
2. 02 Casarett & Doull's Essentials of Toxicology (Lange) – 3rd Ed. (2015) By Curtis D. Klaassen and John B. Watkins
3. 03 Coleman MD. Human Drug Metabolism, Wiley-Blackwell, Oxford, 2020

Learning Outcomes

1. L01 Be able to describe the mechanism of toxicity and ADME of major toxic substances.
2. L02 Be able to classsify and compare the therapeutic drugs and illustrate how they should be utilized in cases of poisonings.
3. L03 Be able to critically assess the current environmental issues related to industrial and commercial pollution.
4. L04 Be able to evaluate the potential dangers and adverse effects of materials that are used daily.
5. L05 Be able to conduct related laboratory experiments and interpret the obtained scientific results accordingly.
6. L06 - Classify (3) and assess (5) the interactions of drug drug, drug herbal and drug life style factors at the kinetic and dynamic level SOLO 4
7. L07 Explain (3) the toxic mechanisms of pesticides and metals and compare (4) antidotal therapy in intoxications caused by them SOLO 3.5
8. L08 Describe (3) and assess (5) the toxic mechanisms of drugs and other xenobiotics on target organs such as kidney, nervous system, liver, and lung SOLO 4
9. L09 Explain (3) and assess (5) the toxicity mechanisms of organic solvents SOLO 4
10. L10 Conduct (3) related laboratory experiments and interpret (5) the obtained scientifc results accordingly SOLO 4

Program Outcomes

1. P01 Gain the ability to apply the Pharmacy profession.
2. P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
3. P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
4. P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
5. P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
6. P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
7. P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
8. P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
9. P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
10. P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
11. P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
12. P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
13. P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
14. P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix