PHAR304 - PHARMACEUTICAL CHEMISTRY-III

Course Description

The main topics are chemotherapeutics such as antiseptics, antiprotozoals, antimalarials, antifungals, antivirals, antineoplastics, antibacterials; antiemetics, antiacides and antiulcer drugs, laxative-purgatives, antidiarhetics, antiallergics, local anesthetics, vitamines, diagnostic compounds and hormones. Antineoplastic and antihistamine drugs, gastrointestinal system drugs, steroids, vitamins, minerals, electrolytes, Parkinson's and Alzheimer's medications, menopause-prostate-osteoporosis drugs, oral and parenteral drugs for nutrition, peptidomimetics, radiopharmaceuticals are also covered. Basic principles of quantitative analysis covering titrimetric methods such as neutralisation, oxido-reduction, complexometry, nitritometry and their application in drug analysis. Also spectrophotometric methods, derivative spectroscopy, quantitative analysis in drug mixture, the principles and applications of the chemical and instrumental techniques such as ultraviolet, infrared, nuclear magnetic resonance and mass spectroscopy of qualitative analysis and structural elucidation of drugs will be covered.

PHARMACEUTICAL CHEMISTRY-III

Evaluation Tools (Active Term)

Item	Type	Weight (%)
Phar304-Midterm	Midterm	30
Phar304-Final	Final	45
Phar304-Laboratory	Quiz	25
Total		100

Course outcomes

01 Analyze the structure activity releationship between the receptor/target and the drug
02 Argue molecular structures of the drugs
03 Structure the synthesis reactions of particular drugs
04 Derive IUPAC nomenclature of the medicines
05 Describe working mechanisms and the metabolism of the medicines

Course Syllabus

Week	Topic
Week 1	IntroExplain the molecular and cellular basis of cancer development and describe the major biological processes involved in carcinogenesis and the general principles of anticancer drug therapy.duction to chemotherapeutic agents, Penicillins
Week 2	Explain the development and progression of infectious diseases and describe the fundamental principles of antimicrobial chemotherapy, including selective toxicity and mechanisms of antimicrobial action.
Week 3	Classify anticancer drugs according to their chemical structures and mechanisms of action and explain how major anticancer drug classes interfere with cancer-cell proliferation and survival
Week 4	Classify antibiotic drugs according to their chemical structures and mechanisms of action and explain their effects on major bacterial targets, including cell-wall synthesis, protein synthesis, nucleic acid synthesis, and metabolic pathways.
Week 5	Explain the mechanisms of action of major chemotherapeutic agents and correlate their molecular targets and mechanisms with their therapeutic effects and major adverse effects.
Week 6	Explain the mechanisms of action of major antibiotic agents and relate their molecular targets to antibacterial activity, spectrum of action, resistance mechanisms, and therapeutic applications.
Week 7	Describe the principles of synthesis and bioactivation of selected anticancer drugs, and explain how metabolic activation or structural modification can influence their pharmacological activity.
Week 8	Midterm exam
Week 9	Explain the relationship between the chemical and physicochemical properties of anticancer and antibiotic agents and their pharmacokinetic and pharmacodynamic profiles, including absorption, distribution, metabolism, elimination, target interactions, and dose–response relationships.
Week 10	Explain the fundamental principles of chemoinformatics and computer-aided drug design, including molecular representation, molecular descriptors, molecular similarity, virtual screening, and structure–activity relationship analysis.
Week 11	Apply advanced chemoinformatics and molecular modeling software to design and analyze drug molecules, including molecular visualization, target–ligand interaction analysis, molecular docking, and prediction of pharmacodynamic properties.
Week 12	Evaluate the pharmacokinetic, drug-likeness, and ADMET profiles of drug candidates using advanced computational tools, and interpret computational results to guide structural optimization and drug-design decisions.
Week 13	Explain the chemical classification, mechanisms of action, and physicochemical properties of NSAIDs, and relate their chemical structures to cyclooxygenase inhibition and their anti-inflammatory, analgesic, and antipyretic effects.
Week 14	Analyze the structure–activity relationships, pharmacokinetic and pharmacodynamic properties of NSAIDs, and correlate structural features with COX selectivity, potency, therapeutic applications, metabolism, and adverse-effect profiles.
Week 15	Final exam

Reference Books & Course Materials

01 Introduction to Medicinal Chemistry
02 Foye's Principles of Medicinal Chemistry

Learning Outcomes

L01 Students will gain an understanding of
L02 Analyze the structure-activity relationship between the receptor/target and the drug SOLO 4
L03 Argue molecular structures of the drugs SOLO 4
L04 Structure the synthesis reactions of particular drugs SOLO 4
L05 Derive IUPAC nomenclature of the medicines SOLO 4
L06 Describe working mechanisms and the metabolism of the medicines SOLO 3

Program Outcomes

P01 Gain the ability to apply the Pharmacy profession.
P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix

LO	P01	P02	P03	P04	P05	P06	P07	P08	P09	P10	P11	P12	P13	P14	Average
L01	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
L02	4	3	4	5	4	4	2	0	3	5	3	3	3	5	3.43
L03	4	4	4	3	5	5	3	3	3	5	3	3	3	5	3.79
L04	4	4	3	4	4	4	3	3	3	4	4	3	3	5	3.64
L05	4	4	4	4	4	4	3	3	3	5	3	4	3	5	3.79
L06	4	3	4	4	4	3	3	3	3	4	3	3	3	5	3.5