BIOCHEMISTRY

Course Description

The main topics are water and pH, the structure of carbohydrates, lipids, amino acids, proteins and nucleic acids, enzymes including mechanism of action, enzyme kinetics, regulation of enzyme activity, coenzymes, and bioenergetics. The structure of proteins, carbohydrates and lipids, cell membranes, are covered as well as structures and mechanisms of action of several membrane channels, pumps and receptors. Transducing and storing energy is covered as part of the introduction to metabolism. The molecular details of nucleic acid structure, DNA replication, RNA synthesis, processing and regulation, gene expression, protein synthesis, techniques in protein biochemistry will also be covered. Transcription of DNA into RNA and the translation at the ribosome are among the emphasized areas as well as protein/enzyme structure/function, macromolecule structures.

BIOCHEMISTRY

Evaluation Tools (Active Term)

Course outcomes

No course outcomes have been defined yet.

Course Syllabus

Reference Books & Course Materials

1. 01 FUNDAMENTALS OF BIOCHEMISTRY by VOET, VOET, PRATT, Upgrade Edition, ISBN:0-471-41759-9
2. 02 Harper's Illustrated Biochemistry by Murray et al., McGraw Hill, 29th Ed.
3. 03 Lehninger - Principles of Biochemistry, 8th ed.

Learning Outcomes

1. L01 Explain the properties of water, ionization, Keq, pH and pKa in relation to water and other biomolecules and compute formulas in relation to pH, pKa and acid/base concentrations SOLO 3.5
2. L02 Distinguish and characterize the different classes of amino acids, their unique features and isoelectric points, and identify and explain different levels of protein structures SOLO 3.5
3. L03 Outline the process of protein folding and degradation and explain and characterize protein metabolism, amino acid deamination, and protein metabolism disorders SOLO 3.6
4. L04 Outline and describe the steps of protein purification SOLO 3
5. L05 Identify and describe the different categories and functions of carbohydrates SOLO 2.5
6. L06 Identify and describe the different categories and functions of lipids SOLO 2.5
7. L07 Explain DNA and RNA structures, nucleotides and outline research that led to the discovery of DNA and inheritance, including DNA mutations and DNA repair SOLO 3.5
8. L08 Outline the stages and characteristics of DNA replication, transcription and translation and the roles of enzymes involved, including post transcriptional and post translational modifications SOLO 3
9. L09 Describe the functions of enzymes and their characteristics and compute enzymatic parameters such as Km, Vmax, 1/2Vmax and use the Michaelis-Menten equation with and without inhibitors SOLO 3

Program Outcomes

1. P01 Gain the ability to apply the Pharmacy profession.
2. P02 Interpret the accuracy and reliability of the current theoretical and practical knowledge in the field of pharmacy, as well as being able to follow and evaluate innovations.
3. P03 Practically apply the knowledge they gain on pharmaceutical sciences. The acquired knowledge and skills allow the graduates to act as the closest health consultant to the public with the ability to inform the public.
4. P04 Evaluate and apply current technology related to basic subjects and principles covering pharmacy and health sciences and take part in in-service training seminars.
5. P05 Know the risks and evaluation of the use of drugs and other chemicals and safe laboratory practices (GMP).
6. P06 Acquire the ability to interpret the findings obtained by qualitative and quantitative measurements and to reach valid scientific results from the data.
7. P07 Prepare pharmaceuticals and provide guidance on the use of pharmaceutical products.
8. P08 Design research and develop projects related to pharmaceutical products; manage and share the results.
9. P09 Be competent to accurately and intelligibly communicate and transfer knowledge about prescription content and pharmaceutical products to the patient / user. The graduates are trained on taking necessary precautions for safe drug usage and encouraging rational drug use, as well as providing consultancy and supervision.
10. P10 Work in an interdisciplinary environment. Graduates can cooperate with other professional groups, participate in vocational training and activities, have proper knowledge and communication skills.
11. P11 Take part in social responsibility projects related to health. Graduates have awareness on sustainable environment and participate in activities and practices related to their profession.
12. P12 Open a community pharmacy, also work in hospital pharmacies, can work in different fields related with pharmaceuticals, cosmetics, medical and herbal products, as well as production and quality control in the pharmaceutical industry. Takes part in the professional development of herself/himself, her/his colleagues and pharmacy students.
13. P13 Implements the legal and professional law and ethics as a health professional, in issues concerning public health.
14. P14 Knows and applies the processes related to drug design from natural or synthetic sources, as well as development, preparation, analysis and metabolism of drugs in the human body.

Po-Lo Matrix