CHRONOBIOLOGY AND CHRONOPHARMACOLOGY
- Course
- PSCI623 - CHRONOBIOLOGY AND CHRONOPHARMACOLOGY
- Department
- Pharmaceutical Sciences - English - PhD
- Course Type
- Course
- Status
- Required
- Language
- English
- Credit
- 3
- ECTS
- 8
- T+P+L
- 3 + 0 + 0
- Course Coordinator(s)
- -
- Prerequisite
- -
- Keywords
Course Description
The main topics are molecular basis of biological rhythms, internal clocks and their messengers, principles of clinical chronobiology, physiology and pharmacology of melatonin, data processing in chronobiological studies, rhythmic variations in the activity of gastrointestinal, hepatic, renal, respiratory, cardiovascular, endocrine systems in healthy and unhealthy conditions, chronobiology of human sleep and sleep disorders, chronobiology of blood pressure and chronotherapy in cardiovascular disorders, nocturnal asthma and chronotherapy, chronobiology in laboratory medicine, cancer chronobiology and treatment approaches, and administration time dependent differences in pharmacokinetics and pharmacodynamics of drugs. Chronobiological implications for the treatment of sleep disorders, chronotoxicology, pain management and shift-work related outcomes of health will also be considered.
CHRONOBIOLOGY AND CHRONOPHARMACOLOGY
Evaluation Tools (Active Term)
No evaluation items have been defined.
Course outcomes
- 01 Be able to explain importance of biological rhythms in human health
- 02 Be able to describe blood pressure rhythm and related therapy principles
- 03 Be able to describe biological rhythm involvement in several disorders
- 04 Be able to explain shiftwork related impairment in health
- 05 Be able to define importance of drug administration time in some clinical conditions
Course Syllabus
| Week | Topic |
|---|---|
| Week 1 | Introduction-Biological Rhythms |
| Week 2 | Melatonin-Hormone and Drug |
| Week 3 | Importance of Drug Administration Time |
| Week 4 | Chronobiology and Chronopharmacology of Pain |
| Week 5 | Nocturnal Asthma and Chronotherapy |
| Week 6 | Chronobiology and Chronopharmacology of Gastrointestinal System |
| Week 7 | Chronobiology and Chronopharmacology of Endocrine System |
| Week 8 | Data Processing in Chronobiologic Studies |
| Week 9 | Chronobiology of Sleep and Sleep Disorders |
| Week 10 | Chronobiology and Chronopharmacology of Cardiovascular System |
| Week 11 | Chronobiology in Laboratory Medicine |
| Week 12 | Cancer Chronobiology and Chronotherapy |
| Week 13 | Chronotoxicology |
| Week 14 | Shiftwork and Health Consequences |
| Week 15 | Overall Evaluation of Chronoscience |
Reference Books & Course Materials
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Learning Outcomes
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Program Outcomes
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Po-Lo Matrix
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