PHARMACEUTICAL BIOTECHNOLOGY
- Course
- PHAR401 - PHARMACEUTICAL BIOTECHNOLOGY
- Department
- Pharmaceutical Sciences - English - PhD
- Course Type
- Scientific Preparation
- Status
- Required
- Language
- English
- Credit
- 0
- ECTS
- 0
- T+P+L
- 0 + 0 + 0
- Course Coordinator(s)
- Dr. Veysi PISKOBULU
- Prerequisite
- -
Course Description
Applications of recombinant DNA technology in the pharmaceutical sciences, PCR and mutagenesis in gene engineering, biotechnology derived protein products, vaccines, monoclonal antibodies and pharmaceutical applications, gene therapy, and viral and non-viral delivery of gene therapeutics, usage of transgenic animals for production of biopharmaceuticals, analytical methods used in pharmaceutical biotechnology, mechanisms and causes of protein purification/destabilization, methods used to evaluate protein pharmaceuticals, developments in protein drug delivery, regulatory aspects of biotechnology-based pharmaceuticals, principles of cell culture, preparation, and maintenance of cell lines will be covered. Vaccines, immunoglobulin products, monoclonal antibodies, products containing cells or microorganisms, interferons, therapeutic proteins derived from plants, animals, humans, or microorganisms, and recombinant versions of these products, and quality control of biological products and regulatory issues are also included with particular attention to methods.
PHARMACEUTICAL BIOTECHNOLOGY
Evaluation Tools (Active Term)
| Item | Type | Weight (%) |
|---|---|---|
| Midterm | Midterm | 30 |
| Assignment 1 | Assignment | 10 |
| Assignment 2 | Assignment | 10 |
| Final | Final | 50 |
| Total | 100 | |
Course outcomes
- 01 1. Be able to fully evaluate molecular basis of major biotechnology techniques
- 02 2. Be able to comprehend, apply and describe the basic principles of pharmaceutical biotechnology.
- 03 3. Be able to explain important features of new advances in pharmaceutical biotechnology
- 04 4. Be able to search and interpret, critically evaluate and present multidisciplinary scientific articles.
- 05 5. Be able to present on biotechnology methods and techniques using scientific literature.
- 06 6-Pharmaceuticals (including antibiotics, small molecular drugs) produced using Pharmaceutical Biotechnology techniques
- 07 7-Production methodologies in pharmaceutical biotechnology ( recombinant DNA technology, fermentation methods, hybridoma and transgenic technologies)
- 08 8-Obtain knowledge about stem cell technology and therapies, biosimilars, tissue engineering and their associated risk factors and management, ethical and administrative responsibilities of the pharmacist.
- 09 9-Pharmaceutical bionanotechnology, gene based drugs, genetic tests, biobanks, personalized medicine, omics technologies and basics of bioinformatics.
Course Syllabus
| Week | Topic |
|---|---|
| Week 1 | Introduction |
| Week 2 | Protein Structure |
| Week 3 | Molecular Biotechnology—Gene Manipulation and Recombinant DNA Technology |
| Week 4 | Production and Purification of RecombinantProteins |
| Week 5 | Product Analysis—Biophysical and Biochemical Analysis of Recombinant Proteins |
| Week 6 | Case Studies |
| Week 7 | Techniques of Molecular Biotechnology |
| Week 8 | Midterm |
| Week 9 | Midterm |
| Week 10 | Monoclonal Antibodies and Vaccines |
| Week 11 | Genomics and Other ‘OMICS’ Technologies, Personalised Medicine |
| Week 12 | Nucleic Acid and Cell Based Therapeutics—Gene Therapy & Genome Editing Technologies |
| Week 13 | Nucleic Acid and Cell Based Therapeutics—Stem Cell Technology |
| Week 14 | Revision |
| Week 15 | Final |
Reference Books & Course Materials
- 01 Pharmaceutical Biotechnology - Fundamentals and Applications by Crommelin et al., Informa Healthcare USA, ISBN: 1-4200-4437-0
- 02 Pharmaceutical Biotechnology- Concepts and Applications by Gary Walsh, Wiley & Sons, ISBN 978-0-470-01245-1 (PB)
Learning Outcomes
No learning outcomes have been defined.
Program Outcomes
No program outcomes have been defined.
Po-Lo Matrix
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