BIOCHEMISTRY-I

Course Description

The main topics are water and pH, structure of carbohydrates, lipids, amino acids, proteins and nucleic acids, enzymes including mechanism of action, enzyme kinetics, regulation of enzyme activity, coenzymes, and bioenergetics. The structure of proteins, carbohydrates and lipids, cell membranes, are covered as well as structures and mechanisms of action of several membrane channels, pumps and receptors. Transducing and storing energy is covered as part of introduction to metabolism. The molecular details of nucleic acid structure, DNA replication, RNA synthesis, processing and regulation, gene expression, protein synthesis, techniques in protein biochemistry will also be covered. Transcription of DNA into RNA and then translation at the ribosome are among the emphasized areas as well as protein/enzyme structure/function, macromolecule structures.

BIOCHEMISTRY-I

Evaluation Tools (Active Term)

Course outcomes

1. 01 By the completion of the course the students should be able to: 1. Be able to understand biochemical basis of major biochemical systems and reactions.
2. 02 2. Be able to comprehend DNA, RNA, nucleic acid structure/funtion relationships and protein translation.
3. 03 3. Know basic principles of metabolism.
4. 04 4. Be able to search and interpret multidisciplinary scientific articles.
5. 05 5. Be able to comprehend the basics of nucleic acids and DNA technology, biochemistry lab techniques.
6. 06 Understand major metabolic pathways of the body, enzymes involved and their functioning mechnaisms

Course Syllabus

Reference Books & Course Materials

1. 01 FUNDAMENTALS OF BIOCHEMISTRY by VOET, VOET, PRATT, Upgrade Edition, ISBN:0-471-41759-9
2. 02 Harper's Illustrated Biochemistry by Murray et al., McGraw Hill, 29th Ed.
3. 03 Nelson, D. L., & Cox, M. M. (2017). Lehninger Principles of Biochemistry (7th ed.). W.H. Freeman.

Learning Outcomes

1. L01 1. Identify (2) and classify (3) biomolecules.
2. L03 3. Apply (4) biomolecules to metabolism..
3. L04 4.Will be able to summarize (4)the chemical reactions in a living cell.
4. L05 5. Will define(1) and count(1) the energy used and produced within the living cell.
5. L06 6.Will be able to define the difference between hormones and neurotransmitters

Program Outcomes

1. P01 1. Applies foundational nursing knowledge to meet individual, family, and community health needs by providing person-centred care that respects dignity, autonomy, privacy, and informed consent.
2. P02 2. Applies professional standards and quality management principles by using risk assessment, incident/near-miss reporting, audit/feedback, and continuous improvement to strengthen patient safety.
3. P03 3. Integrates theoretical and practical knowledge to deliver holistic preventive, curative, and rehabilitative nursing care by demonstrating therapeutic communication, empathy, and culturally safe practice.
4. P04 4. Delivers evidence-based, high-quality care using health information and communication technologies by documenting accurately, protecting confidentiality/data security, and using clinical technologies safely and appropriately.
5. P05 5. Identifies, analyses, and addresses healthcare problems by formulating clinical questions, searching and appraising evidence, applying findings to practice, and evaluating outcomes using a systematic, research-informed approach.
6. P06 6. Manages nursing care by prioritising, planning, implementing, and evaluating interventions; escalating concerns appropriately; and demonstrating accountability through accurate documentation and responsible delegation/supervision.
7. P07 7. Collaborates effectively within interdisciplinary/multidisciplinary teams by sharing timely information, respecting roles, engaging in constructive conflict management, and contributing actively to shared decision-making.
8. P08 8. Maintains lifelong learning by setting professional development goals, seeking and using feedback, engaging in reflective practice/portfolio work, and updating practice according to current scientific and technological developments.
9. P09 9. Plans and implements community-oriented projects and health promotion activities by using population data, collaborating with stakeholders, advocating for equitable health, and evaluating the impact of initiatives on community/public health.
10. P10 10. Upholds ethical principles by maintaining confidentiality, obtaining informed consent, ensuring fairness/non-discrimination, managing professional boundaries, and reporting unethical or unsafe practices according to regulations.
11. P11 11. Contributes to quality and professional development processes by participating in institutional quality activities , supporting in-field/out-of-field education through mentoring/teaching, and representing the nursing profession appropriately at national and international levels.
12. P12 12. Communicates professionally in at least one foreign language to access and use international evidence, collaborate with global peers, and provide safe, respectful communication for diverse populations.

Po-Lo Matrix